The Crohn's & Colitis Foundation (CCF) is a volunteer-driven non-profit organization dedicated to finding cures for Crohn's disease and ulcerative colitis and improving the quality of life of children and adults affected by these digestive diseases. Founded by Shelby Modell and Irwin M. Rosenthal, and formerly known as National Foundation for Ileitis and Colitis and Crohn's and Colitis Foundation of America, it was incorporated on December 17, 1965. CCF has more than 50,000 members, served by the national headquarters, as well as over 40 chapters nationwide.

Research, educational workshops and symposia, together with CCF's scientific journal, Inflammatory Bowel Diseases, enable medical professionals to keep pace with this rapidly growing field. The National Institutes of Health has commended the Foundation for "uniting the research community and strengthening IBD research". The Foundation ranks third among leading health non-profits in the percentage of expense devoted to mission-critical programs, with at least 80 cents of every dollar CCF spends going toward medical research, professional education, and patient support.